2. Signaling Pathways
  3. GPCR/G Protein
  4. LPL Receptor

LPL Receptor

Lysophospholipid Receptor

LPL Receptor

Related Products

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LPL Receptor (Lysophospholipid Receptor) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg". LPL receptor ligands bind to and activate their cognate receptors located in the cell membrane. Depending on which ligand, receptor, and cell type is involved, the activated receptor can have a range of effects on the cell. These include primary effects of inhibition of adenylyl cyclase and release of calcium from the endoplasmic reticulum, as well as secondary effects of preventingapoptosis and increasing cell proliferation. Type: LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, LPAR6, S1PR1, S1PR2, S1PR3, S1PR4, S1PR5.

LPL Receptor Isoform Specific Products:

LPL Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-132847
    Vibozilimod
    		Agonist 99.52%
    Vibozilimod (SCD-044, Example 33) is an orally active and selective S1PR1/EDG1 agonist with an EC50 of less than 1 nM. Vibozilimod has immunomodulatory activity and can reduce the number of lymphocytes. Vibozilimod can be used in the research of inflammatory diseases such as psoriasis and atopic dermatitis.
    Vibozilimod
  • HY-10968A
    CYM5442 hydrochloride
    		Agonist
    CYM5442 hydrochloride is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM. CYM5442 hydrochloride is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 hydrochloride activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 hydrochloride can easily penetrate the central nervous system (CNS).
    CYM5442 hydrochloride
  • HY-125881
    ASP1126
    		Agonist
    ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile.
    ASP1126
  • HY-135432
    Etrasimod arginine
    		Modulator
    Etrasimod arginine is an orally available S1P receptor modulator that is a potent full agonist of the S1P1 receptor and has partial agonist activity at S1P4. Etrasimod arginine reduces inflammation in a CD4+CD45RBhigh T cell-transferred mouse colitis model.
    Etrasimod arginine
  • HY-148115
    S1p receptor agonist 2
    		Agonist
    S1p receptor agonist 2 (compound 1) is an agonist of S1P5 receptor, exhibits selectivity over the S1P1 and/or S1P3 receptors. S1p receptor agonist 2 can be used for endogenous SIP signaling system research, and alleviating or preventing CNS disorders research, such as neurodegenerative disorders.
    S1p receptor agonist 2
  • HY-11063S1
    Fingolimod-d4 hydrochloride
    		Antagonist 99.0%
    Fingolimod-d4 (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant.
    Fingolimod-d<sub>4</sub> hydrochloride
  • HY-P991310
    Lpathomab
    		Inhibitor
    Lpathomab (LT3015; LT-3000) is a human IgG1 monoclonal antibody (mAb) targeting LPA. Lpathomab reduces the release of IL-8 and IL-6 cytokines in SKOV3 cells and blocks LPA-triggered tumor cell migration. Lpathomab reduces neovascularization in Matrigel plug and CNV models. Lpathomab inhibits brain injury in the CCI mouse model. Lpathomab can be used in the study of brain injury, ovarian cancer, diabetic neuropathy, and spinal cord injury. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
    Lpathomab
  • HY-N15794
    AzoLPA ammonium
    		Activator
    AzoLPA ammonium is a photoswitchable lipid that activates the Lysophosphatidic acid 1-5 (LPA1-5) receptors’ signaling.
    AzoLPA ammonium
  • HY-RS12405
    S1pr5 Rat Pre-designed siRNA Set A
    		Inhibitor

    S1pr5 Rat Pre-designed siRNA Set A contains three designed siRNAs for S1pr5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    S1pr5 Rat Pre-designed siRNA Set A
  • HY-173322
    Lp(a)-IN-8
    		Inhibitor
    Lp(a)-IN-8 (compound 15) is an Lp(a) inhibitor. Lp(a) is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD).
    Lp(a)-IN-8
  • HY-149004A
    SLF1081851 TFA
    		Inhibitor
    SLF1081851 (TFA) is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 (TFA) plays a key role in development and immune system.
    SLF1081851 TFA
  • HY-157787
    Ginkgolic acid 2-phosphate
    		Agonist
    Ginkgolic acid 2-phosphate is a potent sphingosine 1-phosphate agonist. Ginkgolic acid 2-phosphate induces ERK phosphorylation. Ginkgolic acid 2-phosphate interactes with S1P1.
    Ginkgolic acid 2-phosphate
  • HY-145362
    S1P1 agonist 4
    		Modulator
    S1P1 agonist 4 has a better profile in both potency (EC50 < 0.05 mg/kg) and predicted human half-life (t1/2 ∼ 5 days).
    S1P1 agonist 4
  • HY-156408
    Spns2-IN-1
    		Inhibitor
    Spns2-IN-1 is a potent inhibitor of Spns2-dependent S1P transport (Spns2), with IC50 of 1.4±0.3 μM that plays an important role in immune response.
    Spns2-IN-1
  • HY-12355S
    Siponimod-d11
    		Modulator
    Siponimod-d11 (BAF-312-d11) is deuterium labeled Siponimod (HY-12355). Siponimod is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod is selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4, with EC50s of 0.4, 0.98, >10000, >1000, and 750 nM, respectively. Siponimod can be used for multiple sclerosis (MS) research.
    Siponimod-d<sub>11</sub>
  • HY-173325
    LPA2 antagonist 6
    		Antagonist
    LPA2 antagonist 6 (example 2) is an antagonist of Lp(a). LPA2 antagonist 6 inhibits Lp(a) formation with an IC50 value of 2.33 nM. LPA2 antagonist 6 can be used in the research of cardiovascular disease.
    LPA2 antagonist 6
  • HY-178491
    S1PR1 agonist 3
    		Agonist
    S1PR1 agonist 3 (Compound Y18) is a highly selective S1PR1 receptor agonist (EC50=0.98 nM). S1PR1 agonist 3 is promising for research of autoimmune diseases such as multiple sclerosis and ulcerative colitis.
    S1PR1 agonist 3
  • HY-120409
    AB1
    		Inhibitor
    AB1 is a highly selective S1P2 receptor antagonist (IC50=3.5 nM). AB1 inhibits sphingosine-1-phosphate (S1P) signaling, suppressing tumor cell migration, angiogenesis, and profibrotic mediator CTGF expression while inducing apoptosis. AB1 is promising for research of solid tumors.
    AB1
  • HY-W701470
    W140 hydrobromide
    		Antagonist
    W140 hydrobromide is a S1P1 antagonist with the Ki of 2.84 μM, and can enhanceof capillary leakage and restoration of lymphocyte egress.
    W140 hydrobromide
  • HY-RS12395
    S1pr2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    S1pr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for S1pr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    S1pr2 Mouse Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
LPL Receptor Isoform Comparison

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